代谢性疾病及治疗药物与肝癌的相关性研究进展

代谢性疾病与肝癌发病密切相关,其作用机制可能与体内胰岛素抵抗、高血糖、脂肪细胞因子分泌异常、内质网应激、肠道相关菌群失调、血脂异常等因素有关。研究表明治疗代谢性疾病的药物如二甲双胍和阿托伐他汀可以降低肝癌的发病和复发风险。本文就代谢性疾病及治疗药物与肝癌的相关性研究作一综述。     

Collapse safety margin-oriented seismic retrofit strategy for corroded reinforced concrete frames using fibre reinforced plastics

Considering residual service life, this paper presents a collapse safety margin-oriented seismic retrofit strategy for corroded reinforced concrete (RC) frames using fibre reinforced plastics (FRP). With the assumed uniform corrosion model, corrosion-induced initial damage combined with subsequent earthquake-induced damage is identified by the multi-mode-based global damage model developed previously. The collapse-level earthquake intensity determined by incremental dynamic analyses (IDA) with the damage model and the maximum considered earthquake (MCE)-level intensity considering residual service life are combined to generate the time-variant collapse safety margin assessment of corroded RC structures. Based on this assessment, the collapse safety margin-oriented FRP seismic retrofit strategy is proposed and demonstrated on a 4-storey frame. The damage model originally developed for earthquake scenarios has also exhibited its rationality for characterising corrosion-induced initial damage and its influence on coupled damage development with subsequent earthquake excitation. Seismic retrofitting with FRP composites should consider the effects of the corrosion development stage, target collapse safety margin and residual service life. FRP retrofits can cause decreases in the MCE-level collapse probability and increases in the collapse resistance of corroded RC structures. Retrofitting carried out at different times achieves different efficiencies and different time-variant collapse safety margins within the residual service life.     

浅谈加入WTO后的工程造价

介绍了国际服务贸易总协定的一般责任和义务 ,分析了加入WTO对工程造价的机遇及对策 ,提出了加入WTO对工程造价的挑战 ,以提高企业自身素质 ,在市场竞争中不断发展壮大。     

混凝土中氯离子迁移的影响因素研究

从混凝土暴露时间、胶凝材料吸附作用、环境温度、应力和裂缝状态等方面考察了它们对混凝土中氯离子迁移的影响、结果表明，混凝土的氯离子表观扩散系数随暴露时间的推移而衰减，且掺有掺合料的混凝土其衰减程度要大于纯水泥混凝土；矿物掺合料对氯离子的吸附结合能力要比水泥强，胶凝材料对氯离子的吸附结合能力与环境中的氯离子浓度有关；环境温度越高，混凝土中氯离子的迁移速率越大．混凝土所处的应力状态将在多方面影响氯离子在混凝土中的迁移，混凝土中裂缝的存在将促进氯离子在混凝土中的迁移．     

徽州传统民俗文化的经典图式——探寻古民居雕刻装饰的"味"与"道"

徽州古民居装饰雕刻作为明清两朝徽派建筑的重要组成部分和民居装饰艺术的重要标志,在我国传统文化史上留下光辉灿烂的一页。收集整理了详实而生动的传统民俗文化资料和徽雕作品的文脉展示,探寻徽派雕刻与传统民俗文化的历史源流,了解精美之中的民俗典故和人们企盼吉祥生活、家业兴旺的美好愿望,从而揭示徽州民俗文化的丰富内涵及潜藏于其中的伦理道德和儒学思想。     

基于层次分析法的可拓学理论在地下洞室岩体质量评价中的应用

基于可拓工程方法,在物元模型理论的基础上建立了洞室岩体质量评价的物元模型,提出采用层次分析法计算物元模型中各评价指标的权系数的方法。通过实际洞室岩体质量等级的关联度计算,对水布垭水电站地下厂房的围岩岩体质量进行了评价,得出与现场实际相符合的结论。研究结果表明:层次分析法用于确定洞室岩体质量评价指标的权系数是可行的,并且洞室岩体质量的可拓学评价能够较好地反映洞室岩体的质量等级,具有较好的适用性。     

An Independent Perception of Regulation in Practice

The paper reviews the regulation of water companies in England and Wales since 1989 by reference to the historical regulation of utilities in these countries. It considers how comparative competition, service standards and charging arrangements are developing. Particular mention is made of the debates over rates of return and household metering. The conclusion is that regulation, to be effective and appropriate, must be capable of evolution.     

高校商业服务设施研究

通过对大学生消费行为类型现状的分析,从规划布局、营业规格、造型及场所、交往空间、管理等方面指出了现在高校商业服务设施存在的问题,并深层次地分析了其原因,同时给出了相应的改进建议,以完善高校商业服务设施的规划设计。     

对沈大高速公路服务区考察的思考

通过对建筑实例的考察详细地表述了沈大高速公路在改扩建过程中对服务区规划设计、单体建筑为适应未来新的发展趋势而重新定位的实践,尤其在功能拓展、地域个性化风格形式和管理模式的合理定位问题上引发了今后对高速路服务区设计的思考。     

浅谈桥梁的维修与加固

通过论述我国现有桥梁的状况，发现公路桥梁常见病害，分析桥梁病害的起因，介绍了几种桥梁检测与加固的方法，对有效和合理地解决既有公路桥梁的病害问题具有重要意义。